Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

Table 2 Summary of cases used in this study

Case	Clinical diagnosis	Primary pathological diagnosis	Secondary pathological diagnosis	Thal	Braak	CERAD	Gender	Age
Control 1	Normal	AD low		1	II	none	M	88
Control 2	Normal	PART		0	II	none	F	72
Control 3	Normal	No significant pathological findings		0	0	none	F	55
Control 4	Normal	Remote micro-infarcts and calcifications		0	0	none	M	59
MSA-1	MSA-C	MSA		0	0	none	F	67
MSA-2	MSA-P	MSA	AD intermediate	1	III	moderate	M	71
MSA-3	MSA-P	MSA	AD low	1	I	none	F	60
MSA-4	MSA-P	MSA	PART	0	II	none	M	77
MSA-5	MSA-C	MSA	AD low; CAA	3	I	sparse	M	71
MSA-6	MSA-P	MSA	AD low; CAA	3	I	sparse	F	68
MSA-7	MSA-C	MSA	AD intermediate	3	III	sparse	M	59
MSA-8	MSA-P/C	MSA	PART; CAA	0	I	none	F	66
MSA-9	MSA-P	MSA		0	0	none	F	66
MSA-10	MSA-P/C	MSA		0	0	0	M	53
LBD-1	DLB	LBD diffuse neocortical	AD intermediate; CAA	5	IV	moderate	M	67
LBD-2	DLB	LBD diffuse neocortical	AD high; CAA; LATE (stage 1)	5	V	frequent	F	68
LBD-3	DLB/AD	LBD diffuse neocortical	AD intermediate; CAA; LATE (stage 2)	3	V	frequent	M	83
LBD-4	DLB	LBD diffuse neocortical	AD intermediate; CAA; ARTAG	4	III	sparse	F	67

Listed are the clinical and pathological diagnoses, the sex, age at death and Thal, Braak and CERAD ratings
AD Alzheimer’s disease, ARTAG aging related tau astrogliopathy, CAA cerebral amyloid angiopathy, DLB dementia with Lewy body, LATE limbic-predominant age related TDP-43 encephalopathy, LBD Lewy body disease, MSA-C multiple system atrophy with predominant cerebellar ataxia, MSA-P multiple system atrophy with predominant parkinsonism, PART primary age-related tauopathy

ISSN: 2051-5960