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Table 2 Summary of cases used in this study

From: Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

Case Clinical diagnosis Primary pathological diagnosis Secondary pathological diagnosis Thal Braak CERAD Gender Age
Control 1 Normal AD low   1 II none M 88
Control 2 Normal PART   0 II none F 72
Control 3 Normal No significant pathological findings   0 0 none F 55
Control 4 Normal Remote micro-infarcts and calcifications   0 0 none M 59
MSA-1 MSA-C MSA   0 0 none F 67
MSA-2 MSA-P MSA AD intermediate 1 III moderate M 71
MSA-3 MSA-P MSA AD low 1 I none F 60
MSA-4 MSA-P MSA PART 0 II none M 77
MSA-5 MSA-C MSA AD low; CAA 3 I sparse M 71
MSA-6 MSA-P MSA AD low; CAA 3 I sparse F 68
MSA-7 MSA-C MSA AD intermediate 3 III sparse M 59
MSA-8 MSA-P/C MSA PART; CAA 0 I none F 66
MSA-9 MSA-P MSA   0 0 none F 66
MSA-10 MSA-P/C MSA   0 0 0 M 53
LBD-1 DLB LBD diffuse neocortical AD intermediate; CAA 5 IV moderate M 67
LBD-2 DLB LBD diffuse neocortical AD high; CAA; LATE (stage 1) 5 V frequent F 68
LBD-3 DLB/AD LBD diffuse neocortical AD intermediate; CAA; LATE (stage 2) 3 V frequent M 83
LBD-4 DLB LBD diffuse neocortical AD intermediate; CAA; ARTAG 4 III sparse F 67
  1. Listed are the clinical and pathological diagnoses, the sex, age at death and Thal, Braak and CERAD ratings
  2. AD Alzheimer’s disease, ARTAG aging related tau astrogliopathy, CAA cerebral amyloid angiopathy, DLB dementia with Lewy body, LATE limbic-predominant age related TDP-43 encephalopathy, LBD Lewy body disease, MSA-C multiple system atrophy with predominant cerebellar ataxia, MSA-P multiple system atrophy with predominant parkinsonism, PART primary age-related tauopathy