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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

Fig. 1

Comparison of mbPEGQ30 peptide recruitment and S830 antibody staining on brain sections from zQ175 mice and their wild-type littermates. a Coronal-hemispheres from 5-month-old zQ175 mice and their wild-type littermates, either treated with the mbPEGQ30 peptide or immunolabelled with the S830 antibody (2.5 ×). b Zoomed-in view of cortical, striatal and hippocampal (CA1) regions from 5-month-old zQ175 and wild-type mice, either treated with the mbPEGQ30 peptide or immunolabelled with S830. Black arrows in b point to the defined puncta of the recruitment signal. Purple arrows indicate the diffuse nuclear aggregation; blue arrowheads point to small inclusion bodies. WT = wild-type. Scale bars: a 400 μm; b 10 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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