Fig. 9

Gait pattern of MBP29-hα-syn mice (MBP29 completed) compared to MBP29-hα-syn mice (MBP29 non-completed) at an age of 8 weeks. a–h Analysis of gait parameters by the Catwalk XT gait analysis system indicating ataxic gait of MBP29-hα-syn mice with slow disease progression (n = 24) versus early onset MBP29-hα-syn mice (n = 12) at 8 weeks of age. Note that non-transgenic controls (ntg) are presented as red line for graphical comparisons. Parameters include average speed (a), base of support (BOS) of hind paws (HP) normalized (norm.) to the mean bodyweight (b), the proportion of dual diagonal (c), dual lateral (d), and three paw support (e), as well as swing time of fore paws (FP) (f) and hind paws (HP) (g), and swing speed of FP (h). Paws highlighted in yellow illustrate the respective paw position i.e. dual diagonal (c), dual lateral (d), and three paw support (e). Data represent mean + standard error of the mean. Statistical analyses were performed using Mann–Whitney test; *p ≤ 0.05, **p ≤ 0.01