Fig. 4

Longitudinal evaluation of sensorimotor function in mice with and without spontaneous seizures. a–c Sensorimotor deficits at 1 week, 2 months (controls: n = 18; PTE: n = 17; No-SRS: n = 12) and 5 months (controls: n = 8; PTE, n = 5–6; No-SRS, n = 5) post-TBI by neuroscore (a), beam walk (b; one PTE mouse at 5 months was identified as an outlier) and Simple Neuroassessment of Asymmetric impairment (SNAP) (c). The mean and SEM of control animals are shown by continuous and dotted black lines, respectively. Data are the mean ± SEM and the single values. **p < 0.01 versus 1 week in the same TBI group by a mixed-effect model followed by Tukey’s post hoc multicomparison test. d Recovery rate from 1 week to 2 months post-TBI evaluated by SNAP in PTE (n = 6) and No-SRS mice (n = 5). Data are the mean ± SEM and the single values. #p < 0.05, by two-tailed unpaired t-test. The insert shows the corresponding ROC analysis, p = 0.04