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Table 3 DTI region of interest analysis

From: Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes

Region of interest

Imaging metric

Control

48 h

1 Week

4 Weeks

10 Weeks

ANOVA (F) or

(Mean ± SEM)

Kruskal–Wallis (K)

Hippocampus

FA × 10–1

3.17 ± 0.108

3.74 ± 0.144*

3.76 ± 0.174*

3.04 ± 0.109#

3.13 ± 0.0844#

F = 7.54; p < 0.0001

MD × 10–3

1.04 ± 0.0227

1.02 ± 0.0261

1.02 ± 0.0340

0.984 ± 0.0277

1.11 ± 0.0422

F = 2.16; p = 0.087

RD × 10–3

0.892 ± 0.0163

0.797 ± 0.0204

0.789 ± 0.0228†

0.830 ± 0.0245†

0.936 ± 0.0384#

F = 6.11; p = 0.0004

AD × 10–3

1.42 ± 0.0490

1.43 ± 0.0354

1.42 ± 0.0466

1.29 ± 0.0387

1.45 ± 0.0509

F = 1.92; p = 0.12

Corpus Callosum

FA × 10–1

3.49 ± 0.0667

3.95 ± 0.0980*

3.66 ± 0.147

3.43 ± 0.139#

3.36 ± 0.0869#

F = 4.56; p = 0.003

MD × 10–3

0.939 ± 0.0203

0.904 ± 0.0189

0.918 ± 0.0162

0.914 ± 0.0189

0.883 ± 0.0137

F = 1.29; p = 0.28

RD × 10–3

0.762 ± 0.0169

0.689 ± 0.0763*

0.739 ± 0.0125

0.746 ± 0.0158#

0.726 ± 0.0135

F = 4.24; p = 0.0048

AD × 10–3

1.29 ± 0.0302

1.30 ± 0.0322

1.26 ± 0.0353

1.25 ± 0.0325

1.22 ± 0.0288

F = 1.07; p = 0.38

  1. Bold indicates statistically different according to the following key
  2. SEM = standard error of the mean; * = significance from controls; # = significance from 48 h; † = significance from 10 weeks; FA = fractional anisotropy; MD = mean diffusivity; RD = radial diffusivity; AD = axial diffusivity