Fig. 4
From: Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice
Examples of tau accumulation in the hippocampus of aged wild-type mice following overexpression of Aha1 or FKBP52. High magnification images (100x) were obtained from the hippocampus of a representative animal in the group with the highest tau accumulation. Representative images of tau species and their respective groups are the following: (a) total tau (Dako; AAV9-Aha1), (b) pT231 tau (AAV9-Aha1), (c) AT8 tau (pS202/T205; AAV9-FKBP52), (d) pS396 tau (AAV9-FKBP52), (e) T22 (AAV9-Aha1), and (f) Gallyas-silver (AAV9-FKBP52). Scale bar represents 10 µm