Fig. 3
From: Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice
Overexpression of Aha1 or FKBP52 increases discrete phospho-tau species in aged wild-type mice. Representative images and analysis of hippocampal tissues from 16-months old wild-type mice expressing AAV9-mCherry, AAV9-Aha1, or AAV9-FKBP52 stained for (a, b) total tau (Dako) and phosphorylated tau species: (c, d) pT231 tau, (e, f) AT8 tau (pS202/T205), and (g, h) pS396 tau, as well as (i, j) T22 oligomeric tau and (k, l) Gallyas silver-positive tau. N = 6/AAV. Relative intensity was analyzed by one-way ANOVA followed by Tukey post-hoc test. Statistical significance is indicated by *p < 0.05, **p < 0.01 and ***p < 0.001. Results represented as standard error of the mean (± SEM). Scale bar represents 100 µm; inset scale represents 10 µm