Fig. 5

Tumor-associated macrophages (TAMs): The Cerberus of glioblastoma (GBM). Representation of the main functions of TAMs in promoting GBM, including contributions to tumor progression, immunosuppression, and development of vasogenic cerebral edema. TAMs can be metaphorically compared to the three-headed dog Cerberus from Greek mythology, who guards the Underworld gates, preventing the dead from living. In GBM, TAMs protect the tumor cells from dying and support their living