Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology

Table 2 Top independent loci from the genome-wide association study

CHR	SNP	Gene	Minor/major allele	MAF	Std. beta	p value
8	rs12056505	*MTMR7*	C/T	0.120	0.23	4.66 × 10^–8
8	rs2251983	CSMD3	A/C	0.454	− 0.20	1.00 × 10^–6
1	rs10863241	Intergenic	A/G	0.458	0.20	3.38 × 10^–6
5	rs17291699	OXCT1	C/T	0.065	− 0.19	3.56 × 10^–6
11	rs11020813	LINC01171	C/A	0.101	0.19	4.51 × 10^–6

CHR chromosome, SNP single nucleotide polymorphism, MAF minor allele frequency
Bold text indicates genome-wide significant association (p < 5 × 10^–8)

ISSN: 2051-5960