Table 3 Summary of the most substantial changes in molecular markers relative to the Sham and Saline groups
From: Chronically altered NMDAR signaling in epilepsy mediates comorbid depression
Marker | Saline (post-SE) versus Sham | NI vs Saline | Flxc vs Saline | Flxc + NI vs Saline |
|---|---|---|---|---|
nNOS | – | – | – | – |
ERK1 | – | – | – | – |
pERK1 | – | – | – | – |
pERK1/ERK1 | △ (p = .12, d = 1.41) | – | – | ▲ |
ERK2 | ▼ | – | – | ▲ |
pERK2 | ▼ | – | – | ▲ |
pERK2/ERK2 | – | – | – | – |
ERK1/2 | – | – | – | – |
pERK1/2 | – | – | – | ▲ |
pERK1/2/ERK1/2 | – | – | – | – |
Elk1 | – | – | – | – |
pElk1 | ▼ | – | – | ▲ |
pELK1/ELK1 | ▽ (p = .09, d = 1.40) | – | – | ▲ |
CREB | – | – | – | ▲ |
pCREB | ▼ | – | – | ▲ |
pCREB/CREB | ▽ (p = .33) | – | – | – |
BDNF | – | – | – | ▲ |
cFOS | ▽ (p = .19) | – | – | ▲ |