Fig. 9

Oligodendroglia activation and degenerative change of myelin in nigrosome 1 of controls (Co, a, b) and PD (c, d) patients. Brightfield microscopy of myelin basic protein (MBP) shows a dense and rather homogeneous network of myelinated fibres in controls (a). In PD, myelinated fibres appear less dense (c). Additionally, in PD an increase of anti-Olig2 positive oligodendrocytes is visible (arrows, d). Scale bar 50 µm