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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Prolonged activation of cytomegalovirus early gene e1-promoter exclusively in neurons during infection of the developing cerebrum

Fig. 6

Comparison of MCMV e1-pro activity as a reporter of EGFP in neonatal mouse cerebrums infected with rMCMV1373 (ac, g) or rMCMV448 (df) at 3, 7 and 11 dpi. a, d At 3 dpi in both the rMCMV1373- and rMCMV448-infected cerebrums, EGFP fluorescence first appears in the PV. b, e At 7 dpi in rMCMV1373-infected cerebrum, the region of EGFP fluorescence extends from the PV to the HP and CX, while in the rMCMV488-infected cerebrum the region of the fluorescence remains limited to the PV. c, f At 11 dpi in the rMCMV1373-infected cerebrum, EGFP fluorescence remains in the HP and CX, but disappears in the PV, while in the rMCMV488-infected cerebrum the fluorescence disappears entirely. g Enlarged image of c. EGFP+ cells which display a morphology of pyramidal neurons in the CX (upper left inner panel) and the HP (lower right inner panel). CX, cortex; HP, hippocampus; PV, periventricular region. Scale bars: ag 400 µm; g-inner panels 80 µm

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