Fig. 4

Regional distribution of WM and adjacent GM pathology burden in FTLD-Tau and FTLD-TDP. Plots portray the regional distribution of WM and GM pathology burden in FTLD-Tau (a) and FTLD-TDP (b) proteinopathies and their subtypes independent of clinical phenotype. The color scale represents least-square means of ln-transformed WM and GM %AO in each region derived from linear mixed-effects (LME) models adjusting for demographics. Asterisks denote areas of peak pathology burden. Legend: %AO = percentage area occupied by pathology; ACG = anterior cingulate gyrus; ANG = angular gyrus; CBD = corticobasal degeneration; FTLD-Tau = frontotemporal lobar degeneration with inclusions of the tau protein; FTLD-TDP = frontotemporal lobar degeneration with inclusions of the TDP-43 protein; GM = grey matter; MFC = middle frontal cortex; OFC = orbitofrontal cortex; PiD = Pick’s disease; PSP = progressive supranuclear palsy; STG = superior temporal gyrus; Type A/Type B/Type C = subtypes of FTLD-TDP pathology; WM = white matter