Fig. 2

Comparisons of absolute and relative WM pathology burden between FTLD-Tau and FTLD-TDP groups and subtypes. Group differences between proteinopathies and their subtypes, across all regions examined, in a a digital measure of WM pathology burden (%AO, here with natural logarithmic transformation), and b a relative measure of WM pathology burden (WM-to-GM ratio, here with natural logarithmic transformation). Statistics were performed using a linear mixed-effects (LME) model to account for interdependency of multiple measurements from the same patient; all analyses found a significant effect of proteinopathy group or subtype on WM pathology (p < 0.001). Details of pairwise post-hoc comparisons between subtypes are shown in Supplementary Tables 4 and 6. Legend: %AO = percentage area occupied by pathology; CBD = corticobasal degeneration; FTLD-Tau = frontotemporal lobar degeneration with inclusions of the tau protein; FTLD-TDP = frontotemporal lobar degeneration with inclusions of the TDP-43 protein; MAPT = tau with MAPT gene mutation; PiD = Pick’s disease; PSP = progressive supranuclear palsy; Type A/Type B/Type C/Type E = subtypes of FTLD-TDP pathology; WM = white matter; WM-to-GM ratio = ratio of WM %AO to GM %AO