Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast

Table 11 Correlations between p-tau Thr181 and total tau levels with the discrimination index in a novel object recognition task

Novel object recognition (short-term memory)
p-tau (Thr181) vs. discrimination index	Pearson		Kendall's tau-b		Spearman's rho
p-tau (Thr181) vs. discrimination index	Correlation coefficient	p value	Correlation coefficient	p value	Correlation coefficient	p value
Left anterior cortex	− .132	.716	− .156	.531	− .176	.627
Right anterior cortex	− .373	.289	− .244	.325	− .382	.276
Left Hippocampus	.049	.893	− .067	.788	− .055	.881
Right Hippocampus	− .026	.943	.067	.788	− .006	.987
Left Amygdala	− .015	.967	− .022	.929	− .224	.533
Right Amygdala	− .149	.680	− .156	.531	− .176	.627
Left Posterior Cortex	.545	.104	.511	.040	.527	.117
Right Posterior Cortex	.035	.924	.200	.421	.297	.405
Total tau vs. discrimination index
Left anterior cortex	− .330	.352	− .333	.180	− .491	.150
Right anterior cortex	− .137	.706	.022	.929	.103	.777
Left Hippocampus	.205	.570	.156	.531	.200	.580
Right Hippocampus	.052	.886	.022	.929	.079	.829
Left Amygdala	.337	.340	.289	.245	.382	.276
Right Amygdala	− .042	.908	.156	.531	.176	.627
Left Posterior Cortex	.227	.529	− .111	.655	− .091	.803
Right Posterior Cortex	− .364	.300	− .333	.180	− .479	.162

P-tau Thr181 levels were previously determined by Western blotting with the antibody AT270 at 40 weeks after blast exposure [21]. P-tau levels were correlated with the discrimination index in a novel object recognition task previously found to be affected in the same blast-exposed rats at 33 weeks following blast exposure [80]. Five blast and five control animals were analyzed. Correlations with p values less than 0.05 are indicated in bold

ISSN: 2051-5960