Fig. 6
From: Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients
C1 and C3-microglia show distinct dystrophic morphology compared to homeostatic control microglia a Representative images of the five different morphological subtypes of microglia: homeostatic, activated, dystrophic, phagocytic and macrophage-like. b Controls show predominantly homeostatic and activated microglia, while Alzheimer patients show a variety of homeostatic, activated, phagocytic and dystrophic microglia. c Representative images of C1 and C3-microglia surrounding Aβ-plaques showing dystrophic morphology. d 3D confocal imaging confirms cytorrhexic appearance of FTL+Iba1+-microglia. Scale bar represents 20 μm unless otherwise stated. Colorcoding for IF-images in 6A-C are according to the box in the top right corner. Colorcoding of 3D confocal images are according to the legend adjacent to the images