Fig. 5
From: Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients
C1-microglia (FTL+Iba1+) reflect iron-positive microglia a Number of identified C1-microglia correlates well with number of identified iron-positive microglia (n = 20, Pearson coefficient). Increased number of C1-microglia are associated with higher overall Aβ load (Thal) (b) and Tau Load (Braak) (c). Comparison between APOE4 (n = 6) vs. APOE3 (n = 4) carriers shows increased number of identified Aβ-plaques (d) and similar microglia infiltration (e). Increased prevalence of C1-all-mic (f), no increased proportion of Aβ-plaques infiltrated with C1-mic (Aβ-mic) (g), and significantly increased proportion of C1-microglia infiltrating Aβ-plaques (h). d and e Median, Mann–Whitney U test. Patients AD8 and AD12 were excluded from the APOE comparison analysis as they harbour a familial mutation in the APP and PSEN1 gene, respectively, which could be of more influence than the APOE-genotype