Fig. 4
From: COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI)
Representative images of pathology of illustrative case. Fenestration of the septum pellucidum (a). Cortical pTau in neurons and glia consistent with neurofibrillary tangles of Alzheimer’s disease neuropathologic change and astrocytic pathology of aging-related tau astrogliopathy (b, e; PHF-1), with abundant neurofibrillary tangles also present in hippocampal sector CA1 (d; PHF-1). In addition, frequent neuritic amyloid plaques and cerebral amyloid (arrowhead) were present (c; 6f3d). Elsewhere, numerous cytoplasmic inclusions immunoreactive for phospho-TDP-43 were identified in the dentate granule cell layer (f; 1D3). Within the substantia nigra numerous classical Lewy bodies were present (G; arrow), with frequent cortical Lewy bodies revealed in staining for alpha-synuclein (h; KM51)