Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses

Table 2 Number of retinas analyzed by immunofluorescence at timepoints during disease

nd not done
^aTimepoints are shown in days post inoculation (dpi) with 79A mouse adapted scrapie. In the 79A mouse-adapted scrapie model, mice begin showing clinical signs consistent with scrapie around 105-120dpi and reach clinical endpoint disease at approximately 160dpi. Thinning of the retina begins around 118dpi and likely causes blindness by the disease endpoint.
^bAntigens detected with antibodies described in Table 1
^cNumber of mice tested with each antibody at timepoint range shown
^dData not shown

ISSN: 2051-5960