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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Fig. 6

Single myofibre measurements show reduced force, slower ktr, and normal thin filament length. a In single-myofibre physiology measurements 6-month-old male NebY2303H,Y935X mice had lower mean specific force compared with wild-type littermate controls. b Additionally, the mean ktr (tension redevelopment) was slower in NebY2303H,Y935X mice, however, c V0 was unaffected. These results indicate a potential alteration of myosin cross-bridge kinetics underlying the force depression. Welch’s T-test, *p < 0.05. d The thin filament length was not altered in NebY2303H,Y935X mice

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