Fig. 1

Clinical case presentation. a Time course of the patient’s clinical progression: the initial right frontotemporal (FrTemp) mass was surgically removed and the patient received standard radiotherapy (XRT) and temozolomide (TMZ). At 18 months postresection, 4 new ipsilateral masses occurred: frontal (Fr), temporal (Temp), as well as in the lung and cerebellum near midline, and underwent resections, followed by chemotherapy. b. MRI at the time of recurrence, 18 months following the 1st craniotomy for the initial mass resection. Serial axial T1W post-contrast (T1W-C) images show a multifocal mass comprising a frontal mass (Frontal, green arrows) at the site of the previous resection, and a temporal mass (Temporal, purple arrows). c Coronal T1W post-contrast (T1W-C) images showing rapid growth of a cerebellar mass (blue arrows) between the 2nd and the 3rd craniotomies. d Chest CT with contrast showing a solid mass in the right lung (red arrow)