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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Fig. 2

Wwox knockout in mice leads to the changes in Tc-MEPs. a Representative bilateral Tc-MEPs detected in wild-type control and Wwox knockout mice. When compared to Wwox+/+ mice, significantly reduced amplitudes (b) and increased latencies of Tc-MEPs (c) were determined in Wwox−/− mice at 3 weeks of age. A statistically significant increase in the Tc-MEP latency, but no changes in amplitude, was observed in Wwox+/− mice, indicating that haploinsufficiency of Wwox gene may cause a delay in wave latencies with no effect on their amplitudes. The results are expressed as means ± SEM. n.s., non-significant. *P < 0.05, **P < 0.01

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