Fig. 2

Wwox knockout in mice leads to the changes in Tc-MEPs. a Representative bilateral Tc-MEPs detected in wild-type control and Wwox knockout mice. When compared to Wwox^+/+ mice, significantly reduced amplitudes (b) and increased latencies of Tc-MEPs (c) were determined in Wwox^−/− mice at 3 weeks of age. A statistically significant increase in the Tc-MEP latency, but no changes in amplitude, was observed in Wwox^+/− mice, indicating that haploinsufficiency of Wwox gene may cause a delay in wave latencies with no effect on their amplitudes. The results are expressed as means ± SEM. n.s., non-significant. *P < 0.05, **P < 0.01