Fig. 3
From: Three-dimensional vascular microenvironment landscape in human glioblastoma
GBM BVs show uneven COL-IV distribution reflecting basement membrane disruption and fenestration. a Comparison of high-resolution confocal mosaic in normal CTX and GBM. Original confocal overview and volumetric isosurfaces are shown (large increments in frame are 50 μm). b Luminance surface plot measured along the basement membrane of normal CTX vessel and GBM-associated vessels according to the proliferation index Ki67. c Contrasted transparency of basement membrane in normal CTX (N. CTX) and GBM. d Aspect of altered COL-IV distribution in GBM according to increasing Ki67. e Measurements of relative basement membrane fluorescence in normal CTX (N. CTX) and GBM. f Standard deviation of relative fluorescence of normal CTX and GBM basement membrane