Fig. 5

Distribution and quantification of cholinergic and p75NTR-positive neurons in control and saporin-treated TetO-APPSweInd mice. a–f Photomicrographs of ChAT staining in the medial septum and Diagonal band of Broca (a and d), hippocampus (b and e) and cortex (c and f) in control (a–c) and mu-saporin treated (d–f) TetO-APPSweInd mice. (g–i), Quantification of % area covered by ChAT-positive neurons in the medial septum (g) and fibres in the hippocampus (h) and cortex (i), n = 4–5/group. j–l Quantification of % area covered by ChAT (j) and p75NTR-positive (k) neurons and fibres and the ratio of ChAT:p75NTR expression (l) in the medial septum (MS), hippocampus (Hippo) and cortex of C57BL/6 and TetO-APPSweInd (TETAPP) mice, n = 5/group/strain. Scale bar = 100 μm. *p < 0.05, **p < 0.01,* **p < 0.001