Fig. 3
RGC dendritic loss progresses with age in 3xTg-AD and APPNL-G-F mice. a–e Sholl analysis of all reconstructed RGCs from B6J Control, 3xTg-AD and APPNL-G-F at 6–7 and 12 months comparing single models to show significance. Line represents mean of group at each interval, shaded error zones represent ± SEM. Two-tailed Mann–Whitney U test at each interval distance, *p < 0.05. f Area under the Sholl curve. g Maximum number of Sholl intersections. h Total length of all dendrites. Column Scatterplots f–h data points represent individual cells and error bars correspond to SD. B6J Control 6–7 M: n = 58 cells (6 mice, 6 male), B6/J Control 12 M: n = 114 cells (10 mice, 5 male/5 female), 3xTg-AD 6–7 M: n = 99 cells (9 mice, 9 male), 3xTg-AD 12 M: n = 144 cells (12 mice, 6 male/6 female), APPNL-G-F 6–7 M: n = 94 cells (7 mice, 4 male/3 female mice) and APPNL-G-F 12 M: n = 80 cells (6 mice, 3 male/3 female). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. WT wildtype, AUC area under the Sholl curve