Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease

Table 1 Summary of experiments

	Inoculum	Recipient	Attack rate	Percentage of animals affected
Experiment 1^a	12–14 months old Tg2576 blood	Tg2576	5/5	80–100%
Experiment 2^b	12–14 months old Tg2576 blood cells or plasma	Tg2576	0/4 (cells) 4/6 (plasma)	0% (cells) 66.7% (plasma)
Experiment 3^c	Recombinant Aβ fibrils	APP/PS1	5/6	83.3%
Experiment 4^d	12 months old APP/PS1 blood	APP/PS1	4/5	80%
Experiment 5^d	2–4 months old Tg2576 blood	Tg2576	1/8	12.5%
Experiment 6^d	7–9 months old Tg2576 blood	Tg2576	3/7	42.9%
Experiment 7^d	15–20 months old Tg2576 blood	Tg2576	1/6	16.7%
Experiment 8^e	10% brain homogenate from 12 months old Tg2576	Tg2576	2/2	100%

^aDetailed data for this experiment is shown in Figs. 1, 2 and 3. In the table, results of only two transfusions are included
^bDetailed data for this experiment is shown in Fig. 5
^cDetailed data for this experiment is shown in Fig. 6
^dDetailed data in Additional figures
^eOnly 2 of the 20 injected mice survived to the experimental endpoint

ISSN: 2051-5960