Fig. 1

Representative histopathology findings in MOGHE. a H&E staining of the surgical tissue specimen of a 4-year old boy with frontal lobe epilepsy since age 3.3 years (patient DE-3 in Table 1) revealed clusters of increased oligodendroglial cell density (red arrow on left side). Normal oligodendroglial cell density is visible on the right (black arrow). L6: neocortical layer 6; WM: white matter (applies also to b). b Adjacent section stained with antibody against Olig2. Increased oligodendroglial cell density in WM (red arrow on the left) compared to normal density shown on right (black arrow) is visible. c Section stained with antibody against MAP2 indicating excessive heterotopic neurons in deep WM and grey-white matter junction. d Section stained with antibody directed against CNPase. Arrows indicate patchy areas with hypomyelination. Scale bar in a, b and c = 200 µm, in d = 1 mm