Fig. 2

Survival impact of TERT and 1p/19q statuses in grade II–III gliomas when stratified by Karnofsky Performance Status (KPS) scores. a OS of WHO grade II–III cases (n = 527) stratified by the TERT and 1p/19q statuses. Survival curves of TERT-mutated-1p/19q intact group and TERT-mutated-1p/19q codeleted group were mostly overlapping. b OS of WHO grade IV cases (n = 33) stratified by the TERT and 1p/19q statuses. TERT-mutated-1p/19q intact group showed a tendency towards longer survival compared with that of the TERT-wildtype-1p/19q intact group although the difference was not significant. c TERT-mutated-1p/19q intact cases with a high KPS score (90 or 100) had a favorable prognosis comparable to that of the TERT-mutated-1p/19q codeleted cases. D. When analyzed in the population with a KPS score below 90, TERT mutation without 1p/19q codeletion did not show survival benefit. codel, codeleted; KPS, Karnofsky Performance Status; OS, overall survival.; 5yOS, 5-year overall survival