Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Fig. 3

Microsphere extravasation in vivo is independent of size. a Examples of microspheres (white) scored as “in” (top panel), “going out” (middle panel) and “out” (bottom panel) in coronal brain sections stained postmortem for laminin (green) and i.v. lectin (red) before killing. Scale bar = 50 µm. b Quantification of microsphere extravasation at D1, 3 and 7 for 15 µm (black boxes) and 25 µm microspheres (grey boxes). N = 6–7 animals per time point. Data are depicted as median and IQR (min–max). c An extravasation score between 0 and 2 was calculated per rat to determine whether extravasation rate was dependent on time point and microsphere size (“in” was weighed as 0, “going out” as 1 and “out” as 2). N = 6–7 animals per time point. Data are depicted as median and IQR (min–max). ***P < 0.001, 15 µm D1 versus D7; ###P < 0.001, 20–30 µm D1 versus D7, Kruskal–Wallis with Dunn’s multiple comparison test

Back to article page
\