In vivo RyR1 reduction in muscle triggers a core-like myopathy

Table 2 Analysis of muscle fibers’ diameter

	CTRL diameter (µm)	SEM	Nb fiber	RyR1-Rec diameter (µm)	SEM	Nb fiber	Student t-test	%CTRL
EDL type I	23.6	0.9	700	17.2	0.7	700	p < 0.001*	73
EDL type II	40.0	1.6	600	32.5	1.2	700	p < 0.001*	81
TA type I	33.7	1.9	300	20.0	1.2	300	p < 0.001*	59
TA type II	46.8	2.7	300	35.6	2.1	300	p < 0.001*	76

The diameter of slow (type I) and fast (type II) fibers was quantified in Extensor digitorum longus (EDL) and tibialis anterior (TA) sections of CRTL and RyR1-Rec animals at D75 after NADH-TR staining. Hundred fibers were measured for each muscle. Between 3 and 7 mice in each group
*Represent significant data

ISSN: 2051-5960