Fig. 3
From: Clinical and mutational profiles of adult medulloblastoma groups
Unique occurrence of TP53-mutant large cell/anaplastic WNT medulloblastomas. a TP53 mutations were enriched in adult WNT medulloblastomas, found in 40% (6/15) of cases in this group. b All TP53 mutations in WNT occurred within the p53 DNA binding domain. c 3/6 TP53-mutant adult WNT cases were of large cell/anaplastic histology; (i) 19/F, with missense mutation TP53 V173A; (ii) 20/M, with missense mutation TP53 R175H; (iii) 32/F, with missense mutation TP53 R248W; arrows show nuclear moulding