Fig. 6

Age and AD-related markers increase and Kv4.2 decreases in NeuN + puncta in the DPP6-KO mice. Labeling of individual NeuN + puncta for Aβ (A red, 1:1000, BioLegend), APP (B red, 1:500, Abcam), α-synuclein (C red, 1:200, Novus), and AT180 (D red 1:300, ThermoFisher) is increased in DPP6-KO mice compared to WT (F Aβ; WT, n = 267; DPP6-KO, n = 207; **** = p < 0.0001; G APP; WT, n = 215; DPP6-KO, n = 264; **** = p < 0.0001; H α-synuclein; WT, n = 129; DPP6-KO, n = 221; **** = p < 0.0001; I ΑΤ180; WT, n = 192; DPP6-KO, n = 149; **** = p < 0.0001;); labeling is mainly in the peripheral regions of the NeuN + puncta. In contrast, labeling for the DPP6-associated protein, Kv4.2, is decreased in the NeuN + puncta of DPP6-KO mice compared to WT (E,J WT, n = 116; DPP6-KO, n = 91; **** = p < 0.0001). Scale bars = 2 μm