Fig. 5
Bexarotene effects on cisplatin-induced cognitive impairments. Mice (n = 8 males and 8 females) were treated with cisplatin followed by bexarotene and performance in the puzzle box test for executive function and the novel object and space recognition test of short term memory and spatial orientation was assessed. a The puzzle box test started 7 days after the last dose of Bexarotene treatment. Entry time into the dark compartment in the easy and intermediate trials was similar between groups (See Additional file 1: Supplemental Figure 1). Time required for entry in two trials of the difficult task was recorded and the average time was calculated for each mouse. b NOPRT performance was tested in the week after completion of puzzle box test. The discrimination index was calculated as (TNovel − TFamiliar)/(TNovel + TFamiliar), with the value 0 indicating no preference for the novel object. Results are expressed as mean ± SEM. Two-way ANOVA followed by a Tukey’s multiple comparisons test. ***p < 0.001