Fig. 1

Cisplatin induced white matter changes in myelin density and sheath ultrastructure. a Representative images of Black Gold II staining for myelin in the sensorimotor cortex of mice (n = 4) treated with either two 5-day cycles of PBS or cisplatin. Scale bar = 100 μM. b Percent area positive for Black Gold II was measured in the sensorimotor cortex. c Representative transmission electron microscopy (TEM) images were used to analyze and compare the ultrastructure of myelinated axons in the cortex of PBS and cisplatin treated animals. d Percent of damaged myelinated axons and f myelin thickness were quantified to illustrate the differences between the two treatment groups. MannWhitney U test: *p < 0.05. Results expressed as individual data points and mean ± SD