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Table 3 Braak and Thal associations in LBD-NP and PSP patients

From: Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy

 

Variable

PSP and LBD-NP Combined

PSP

LBD-NP

BETA

SE

L95

U95

p

BETA

SE

L95

U95

p

BETA

SE

L95

U95

p

Thal

ABI3_rs616338_T

0.293

0.268

− 0.233

0.818

0.275

0.287

0.360

− 0.418

0.993

0.425

0.464

0.422

− 0.364

1.292

0.272

Age

0.053

0.006

0.042

0.064

< 1E−07

0.044

0.008

0.028

0.060

5.43E−08

0.023

0.008

0.008

0.038

0.002

Female Sex

0.250

0.086

0.082

0.418

0.004

0.335

0.117

0.106

0.563

0.004

0.614

0.138

0.343

0.884

8.74E−06

PLCG2_rs72824905_G

− 0.101

0.357

− 0.802

0.599

0.777

0.010

0.438

− 0.849

0.870

0.981

0.652

0.733

− 0.785

2.090

0.374

Age

0.053

0.006

0.042

0.064

< 1E−07

0.045

0.008

0.029

0.061

1.93E−08

0.023

0.008

0.008

0.038

0.003

Female Sex

0.245

0.086

0.077

0.414

0.004

0.326

0.117

0.098

0.555

0.005

0.620

0.138

0.350

0.891

7.10E−06

Braak

ABI3_rs616338_T

0.070

0.255

− 0.429

0.569

0.784

− 0.08

0.348

− 0.762

0.603

0.819

0.253

0.367

− 0.466

0.973

0.490

Age

0.074

0.005

0.064

0.084

< 1E−07

0.106

0.008

0.090

0.122

< 1E−07

0.011

0.006

− 0.001

0.024

0.065

Female Sex

0.210

0.079

0.054

0.366

0.008

0.254

0.111

0.036

0.473

0.023

0.594

0.118

0.364

0.825

4.42E−07

PLCG2_rs72824905_G

− 0.822

0.315

− 1.439

− 0.204

0.009

− 0.996

0.397

− 1.773

− 0.218

0.012

− 0.292

0.505

− 1.283

0.698

0.563

Age

0.074

0.005

0.065

0.084

< 1E−07

0.105

0.008

0.090

0.121

< 1E−07

0.011

0.006

− 0.001

0.024

0.064

Female Sex

0.199

0.079

0.043

0.355

0.012

0.249

0.111

0.031

0.467

0.025

0.588

0.118

0.358

0.819

5.88E−07

  1. Nominally significant p values < 0.05 are shown in bold
  2. Results of multivariable ordinal regression using the additive model for association of ABI3_rs616338-T and PLCG2_rs72824905-G with Braak and Thal in patients with PSP, LBD-NP and combined PSP + LBD-NP. Analyses were adjusted for age and sex
  3. SE standard error, L95 lower 95% limit, U95 upper 95% limit