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Table 3 Braak and Thal associations in LBD-NP and PSP patients

From: Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy

  Variable PSP and LBD-NP Combined PSP LBD-NP
BETA SE L95 U95 p BETA SE L95 U95 p BETA SE L95 U95 p
Thal ABI3_rs616338_T 0.293 0.268 − 0.233 0.818 0.275 0.287 0.360 − 0.418 0.993 0.425 0.464 0.422 − 0.364 1.292 0.272
Age 0.053 0.006 0.042 0.064 < 1E−07 0.044 0.008 0.028 0.060 5.43E−08 0.023 0.008 0.008 0.038 0.002
Female Sex 0.250 0.086 0.082 0.418 0.004 0.335 0.117 0.106 0.563 0.004 0.614 0.138 0.343 0.884 8.74E−06
PLCG2_rs72824905_G − 0.101 0.357 − 0.802 0.599 0.777 0.010 0.438 − 0.849 0.870 0.981 0.652 0.733 − 0.785 2.090 0.374
Age 0.053 0.006 0.042 0.064 < 1E−07 0.045 0.008 0.029 0.061 1.93E−08 0.023 0.008 0.008 0.038 0.003
Female Sex 0.245 0.086 0.077 0.414 0.004 0.326 0.117 0.098 0.555 0.005 0.620 0.138 0.350 0.891 7.10E−06
Braak ABI3_rs616338_T 0.070 0.255 − 0.429 0.569 0.784 − 0.08 0.348 − 0.762 0.603 0.819 0.253 0.367 − 0.466 0.973 0.490
Age 0.074 0.005 0.064 0.084 < 1E−07 0.106 0.008 0.090 0.122 < 1E−07 0.011 0.006 − 0.001 0.024 0.065
Female Sex 0.210 0.079 0.054 0.366 0.008 0.254 0.111 0.036 0.473 0.023 0.594 0.118 0.364 0.825 4.42E−07
PLCG2_rs72824905_G − 0.822 0.315 − 1.439 − 0.204 0.009 − 0.996 0.397 − 1.773 − 0.218 0.012 − 0.292 0.505 − 1.283 0.698 0.563
Age 0.074 0.005 0.065 0.084 < 1E−07 0.105 0.008 0.090 0.121 < 1E−07 0.011 0.006 − 0.001 0.024 0.064
Female Sex 0.199 0.079 0.043 0.355 0.012 0.249 0.111 0.031 0.467 0.025 0.588 0.118 0.358 0.819 5.88E−07
  1. Nominally significant p values < 0.05 are shown in bold
  2. Results of multivariable ordinal regression using the additive model for association of ABI3_rs616338-T and PLCG2_rs72824905-G with Braak and Thal in patients with PSP, LBD-NP and combined PSP + LBD-NP. Analyses were adjusted for age and sex
  3. SE standard error, L95 lower 95% limit, U95 upper 95% limit