Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy

Table 3 Braak and Thal associations in LBD-NP and PSP patients

	Variable	PSP and LBD-NP Combined					PSP					LBD-NP
	Variable	BETA	SE	L95	U95	p	BETA	SE	L95	U95	p	BETA	SE	L95	U95	p
Thal	ABI3_rs616338_T	0.293	0.268	− 0.233	0.818	0.275	0.287	0.360	− 0.418	0.993	0.425	0.464	0.422	− 0.364	1.292	0.272
	Age	0.053	0.006	0.042	0.064	< 1E−07	0.044	0.008	0.028	0.060	5.43E−08	0.023	0.008	0.008	0.038	0.002
	Female Sex	0.250	0.086	0.082	0.418	0.004	0.335	0.117	0.106	0.563	0.004	0.614	0.138	0.343	0.884	8.74E−06
	PLCG2_rs72824905_G	− 0.101	0.357	− 0.802	0.599	0.777	0.010	0.438	− 0.849	0.870	0.981	0.652	0.733	− 0.785	2.090	0.374
	Age	0.053	0.006	0.042	0.064	< 1E−07	0.045	0.008	0.029	0.061	1.93E−08	0.023	0.008	0.008	0.038	0.003
	Female Sex	0.245	0.086	0.077	0.414	0.004	0.326	0.117	0.098	0.555	0.005	0.620	0.138	0.350	0.891	7.10E−06
Braak	ABI3_rs616338_T	0.070	0.255	− 0.429	0.569	0.784	− 0.08	0.348	− 0.762	0.603	0.819	0.253	0.367	− 0.466	0.973	0.490
	Age	0.074	0.005	0.064	0.084	< 1E−07	0.106	0.008	0.090	0.122	< 1E−07	0.011	0.006	− 0.001	0.024	0.065
	Female Sex	0.210	0.079	0.054	0.366	0.008	0.254	0.111	0.036	0.473	0.023	0.594	0.118	0.364	0.825	4.42E−07
	PLCG2_rs72824905_G	− 0.822	0.315	− 1.439	− 0.204	0.009	− 0.996	0.397	− 1.773	− 0.218	0.012	− 0.292	0.505	− 1.283	0.698	0.563
	Age	0.074	0.005	0.065	0.084	< 1E−07	0.105	0.008	0.090	0.121	< 1E−07	0.011	0.006	− 0.001	0.024	0.064
	Female Sex	0.199	0.079	0.043	0.355	0.012	0.249	0.111	0.031	0.467	0.025	0.588	0.118	0.358	0.819	5.88E−07

Nominally significant p values < 0.05 are shown in bold
Results of multivariable ordinal regression using the additive model for association of ABI3_rs616338-T and PLCG2_rs72824905-G with Braak and Thal in patients with PSP, LBD-NP and combined PSP + LBD-NP. Analyses were adjusted for age and sex
SE standard error, L95 lower 95% limit, U95 upper 95% limit

ISSN: 2051-5960