Fig. 1

Cell populations analyzed in different RNAScope assays. a Table summarizing the total number analyzed for each cell population, and the number of animals, in every RNAScope assay in young and old animals. b Percentage of pyramidal neurons, interneurons and other cell types, performed in control animals and using the same method as the experimental RNAScope assays. c Percentages of each cell population in every experimental RNAScope assay, in young and old animals. d Representative images of a HsMAPT- (“recipient neuron”, left cell) and a HsMAPT + (right cell). e Consequent gray value histograms extracted from the HsMAPT channel shown in d. e1 Histogram of the HsMAPT- (“recipient neuron”) and e2 HsMAPT + neuron. Scale bar: 15 µm