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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD

Fig. 8

Muscle and axon properties of single and double UBQLN Tg and Non-Tg animals. a Gastrocnemius muscle weight (average for one limb for 3 different mice) at 52 weeks of age. b Transverse sections of the muscle stained with H&E. c Frequency distribution of muscle fiber size (n = 40) averaged for 3 different animals at 52 weeks of age. d Graph of the mean fiber size calculated from the data shown in c. e Changes in axonal number and caliber in L4 nerves of mice expressing the different UBQLN transgenes. f Representative transverse sections (1 μm) of the L4 ventral nerves isolated from male and female 52-week-old animals for the four genotypes. b, c Histograms of the mean frequency in distribution of myelinated axons grouped into 5 μm bins for the four genotypes in males (b) and females (c) (average of 3 animals for each genotype)

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