Fig. 3
From: Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD
Effects of overexpression of UBQLN1 and P497S mutant UBQLN2 proteins on body weight and behavioral performance in male and female mice. a, b Graphs of the average whole body weight changes for the different genotypes conducted at 2 week intervals and the best-fit trend lines for both males (a) and females (b). Number of animals analyzed in each group: Non-Tg (n = 30 M, 28 F), UBQLN1 Tg (UBQ1) (n = 19 M, 19 F), P497S Tg (n = 20 M, 14 F), UBQ1/P497S (n = 8 M, 7 F). c, d Graphs of the rotarod analysis showing the average latency to fall for the different genotypes and best fit trend lines for both males (c) and females (d). Non-Tg (n = 13 M, 23 F), UBQ1 Tg (n = 9 M, 14 F), P497S Tg (n = 14 M, 17 F), UBQ1/P497S (n = 6 M, 6 F). e, f Graphs of the average hind limb grip strengths for the different genotypes and best fit trend lines for both males (e) and females (f). Non-Tg (n = 28 M, 27 F), UBQ1 Tg (n = 19 M, × 19), P497S Tg (n = 22 M, 16 F), UBQ1/P497S (n = 8 M, 7 F)