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Table 4 Correlation of levels of solubility ratios of poly-GP, poly-GA and poly-GR with parameters of clinical severity (age at death, age of onset, disease duration)

From: Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

Ratio soluble DPR/total Poly-GP Poly-GA Poly-GR
Age at death
FC − 0.35 0.20 0.28
TC − 0.67 (0.015) − 0.05 0.15
OC − 0.73 (0.006) − 0.21 − 0.23
Cb − 0.43 0.00 0.25
Age of onset
FC − 0.61 (0.05) − 0.18 0.32
TC − 0.73 (0.006) − 0.08 − 0.03
OC − 0.78 (0.002) − 0.27 − 0.23
Cb − 0.49 (0.09) 0.14 0.40
Disease duration
FC − 0.09 0.24 − 0.22
TC − 0.26 0.03 0.05
OC − 0.36 − 0.07 0.03
Cb − 0.05 − 0.06 − 0.38
  1. Spearman’s rank correlation coefficient ρ is shown for correlation of soluble ratio (over total) of poly-GP, poly-GA and poly-GR in frontal cortex (FC), temporal cortex (TC), occipital cortex (OC) and cerebellum (Cb) with age at death, age of onset and disease duration. Correlation coefficients with statistical significance are shown in bold. For all values showing a statistically significant or a trend of correlation, p-values are specified between brackets