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Table 2 DPR levels are significantly higher in C9orf72-FTD patients than healthy control subjects

From: Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

 

Control

C9orf72-FTD

p-value

GP soluble

1.0 ± 0.07

248 ± 70

0.008

GP insoluble

1.0 ± 0.06

13 ± 1.1

< 0.0001

GA soluble

1.0 ± 0.44

28 ± 13

0.039

GA insoluble

1.0 ± 0.28

31 ± 2.7

< 0.0001

GR soluble

1.0 ± 0.08

1.4 ± 0.09

0.004

GR insoluble

1.0 ± 0.12

3.5 ± 0.31

< 0.0001

  1. The data represent the relative DPR values in the C9orf72-FTD subjects as measured by MSD in comparison to the values measured in the healthy control subjects in frontal, temporal, occipital cortex and cerebellum. Data are shown as mean ± SEM. Right column shows p-values. Statistical analysis: unpaired t-test with Welsch correction
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Acta Neuropathologica Communications

ISSN: 2051-5960

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