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Table 2 DPR levels are significantly higher in C9orf72-FTD patients than healthy control subjects

From: Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

  Control C9orf72-FTD p-value
GP soluble 1.0 ± 0.07 248 ± 70 0.008
GP insoluble 1.0 ± 0.06 13 ± 1.1 < 0.0001
GA soluble 1.0 ± 0.44 28 ± 13 0.039
GA insoluble 1.0 ± 0.28 31 ± 2.7 < 0.0001
GR soluble 1.0 ± 0.08 1.4 ± 0.09 0.004
GR insoluble 1.0 ± 0.12 3.5 ± 0.31 < 0.0001
  1. The data represent the relative DPR values in the C9orf72-FTD subjects as measured by MSD in comparison to the values measured in the healthy control subjects in frontal, temporal, occipital cortex and cerebellum. Data are shown as mean ± SEM. Right column shows p-values. Statistical analysis: unpaired t-test with Welsch correction