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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

Fig. 9

DPR-DPR modifier screens: co-expression of DPRs in the Drosophila Eye. a lighsheet micrographs showing the eye of flies homozygously expressing DPRs under the control of a single copy of the eye specific driver GMR-Gal4 (GMR-Gal4/+). Scale bars 100 μm. b Quantification of the eye phenotypes in flies co-expressing DPRs, compared to heterozygous and homozygous expression of single DPR species (see methods for classification scoring). Co-expression of mCD8-GFP acts as a titration control for GMR-Gal4. The number of flies scored is shown above each bar. Each genotype was scored from a minimum of 3 independent crosses. c Mean overall classification score (± SEM) of genotypes represented in “b

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