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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

Fig. 8

Age-related motor impairment in Drosophila pan-neuronally expressing DPRs. a Median climbing speed of adult Drosophila pan-neuronally expressing (nSyb-Gal4) either AP1000, GA1000, PR1000, GR1000 or mCD8-GFP controls. Outcrossed Canton S flies were used as wild type controls. Flies were assayed at 3, 7, 14, 21, 28 and 42 days post-eclosion. Error bars = SEM. At day 3 a minimum of 10 flies per genotype were assayed. The minimum number of flies at any time point was 7, resulting from lethality during the time course. For full Ns per time point see the Additional file 1: Online resource 8. b Median speed of adult Drosophila pan-neuronally expressing (nSyb-Gal4) either AP1000-GFP, GA1000-GFP, PR1000-GFP, GR1000-GFP or mCD8-GFP or outcrossed Canton S wild type controls at 7 and 28 days post-eclosion. Error bars = SEM. ANOVA with post hoc Dunnett’s multiple comparison to wild type controls ****p < .0001; *p < .05 and Tukey’s multiple comparison between groups (time points) ####p < .0001; ##p < .01. N’s are shown on the graph. Flies for motor assays were from at least 3 independent crosses per genotype

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