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Table 1 Distributions of neuronal and glial tau aggregations

From: Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure

Regions NI Grain Glial inclusions
Frontal cortex + +
Primary motor cortex ++ ++
Temporal cortex + +* +
Insula ++ ++
Subiculum/CA1 ++ ++ ++
CA2-4 + ++ +
Dentate gyrus + +
Parahippocampal cortex ++ ++ ++
Amygdala ++ + ++
Temporal tip ++ ++
Parietal cortex + +
Occipital cortex + +
Neostriatum ++ ++
Globus pallidus ++ ++
Basal nucleus of Meynert ++ ++
Cerebral white matter ++
Pars reticulata of substantia nigra ++ ++
Pars compacta of substantia nigra + +
Tegmentum of midbrain ++ ++
Locus ceruleus + +
Pontine nucleus + +
Medullary reticular formation ++ ++
Anterior horn of spinal cord ++ ++
Dorsal horn of spinal cord + +
  1. −, negative; +, mild; ++, severe; NI, neuronal inclusions; *, only in the occipitotemporal gyrus