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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure

Fig. 4

Double immunofluorescence. Panels ai show anti-AT8 immunohistochemistry in the medullary reticular formation. Tau aggregations are more prominent in the cholinergic neurons of the nucleus ambiguus (ac) than in TH-immunopositive cathecolaminergic neurons in the ventrolateral medullary nucleus (df) or TrOH-immunopositive serotonergic neurons in the raphe nucleus (gi). Panels jl demonstrate occasional immunopositivity of phosphorylated TDP-43 within neurons containing AT8-immunopositive inclusions of the hypoglossal nerve. Abbreviations: ChAT, choline acetyltransferase; N. ambiguus, nucleus ambiguus; N. hypoglossal nerve, nucleus of the hypoglossal nerve; N. raphe, raphe nucleus; TH, tyrosine hydroxylase; and TrOH, tryptophan hydroxylase. Scale bars: ac 50 μm, di 100 μm, and j–l 10 μm

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