Fig. 3

RNAseq shows differences in CNS-immune cell activation between CBE-treated and SVNI-infected mice. a Table summarizing the number of differentially expressed genes from RNAseq analysis of the brains of control, SVNI, CBE, and CBE + SVNI mice 5 DPI. The numbers indicate the numbers of genes that were twofold of control, p < 0.05. n = 3 for each group. b Heat maps of RNAseq data comparing differentially expressed genes in brains of control, SVNI, CBE, and CBE + SVNI mice 5 DPI. A horizontal line shows the expression of a gene in different groups. The expression of such a gene is significantly different in at least one of the pairwise comparisons between different groups. Different colors indicate different levels of gene expression: from red to blue value ranges from high to low, respectively. Clusters numbers are on the left. Data from triplicate samples are shown. Datasets can be found in Additional file 3: Table S2. c Venn diagram of differentially-expressed genes in the brains of 5 DPI SVNI and CBE mice. The numbers of shared and unique genes are listed. Overlap was visualized using BioVenn