Fig. 6
From: Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain
Phosphorylation occupancies of soluble pT111, pT153, and pT217 increase in AD, but pT181 does not in the first cohort. Phosphorylation occupancies at residue a T111 (0N), b T153, and c T217 in brain soluble extracts show staged increases in brains with Abeta pathology and with minimal tau pathology (Abeta+). Occupancies are further elevated in AD cases, in which both Abeta and tau pathology are present. d The phosphorylation occupancy of pT181 was approximately 10% in control brains with no clear modulation due to amyloid and/or tau pathologies. Each bar shows the mean ± SEM of two participants from each group