Fig. 5

Phosphorylation occupancies of select soluble p-tau is highly and linearly correlated with Abeta42 concentrations in AD brain from the first cohort. The phosphorylation occupancies of a pT111 (0N), b pT153, c pT181, and d pT217 in brain soluble extracts showed correlations with soluble Abeta42 (Spearman r = 0.90, r = 0.85, r = 0.70, and r = 0.88, respectively). In contrast, phosphorylation at e pS202 and f pT231 were more-weakly correlated with Abeta42 (Spearman r = 0.54 and r = 0.54, respectively). A total of 19 brain soluble extracts from two AD participants (#5: blue, #6: red) were analyzed (regions: CB, SFG, FP, Temp, Ocp, Thal, Amy, Pons, Pari, and Striatum from #5; CB, SFG, Temp, Ocp, Thal, Amy, Pons, Pari, and Striatum from #6). Open data points indicate data from CB regions containing low amyloid pathology