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Table 1 RAN Translation Peptides in G4C2 repeat transgenic flies and plasmids

From: The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD

Genotype

In (GA) n frame

In (GP) n frame

In (GR) n frame

C9ORF72 sense strand

(GA) n Cterminal 31 AAs

(GP) n Cterminal 34 AAs

(GR) n Cterminal 54 AAs

(GA) nWSGRARGRARG GAAVAVPAPAAAEAQ AVASG*

(GP)nGRGRGGPGGGPGAGLRLRCLRPRRRRRRRWRVGE*

(GR)nGVVGAGPGAGPGRGCGCGACARGGGGAGGGEWVSEEAASWRVAVWGSAAGKRRG*

0+ (G4C2)28 GFP

(GA)28 Cterminal253AAs(GFP)

(GP)28 Cterminal 15 AAs

(GR)28 Cterminal 258 AAs

(GA)28GAWSGRARDP PVAT-GFP*

*(GP)28GRGRGGPGIHRSPPW*

(GR)28GVVGAGPGST... AAYNHYK*

1+ (G4C2)28 GFP

(GA)28 Cterminal 264 AAs

(GP)28 Cterminal 258 AAs (GFP)

(GR)28 Cterminal 20 AAs

(GA)28GAWSGRARDP... KRPRL*

*(GP)28GRGRGGPGIHRS DLEPVAT-GFP*

(GR)28GVVGAGPGSTGQISNRSPPW*

2+ (G4C2)28 GFP

(GA)28 Cterminal 21 AAs

(GP)28 Cterminal 264 AAs

(GR)28 Cterminal 258 AAs (GFP)

(GA)28GAWSGRARDPPVRSRNRSPPW*

*(GP)28GRGRGGPGIH.... KRPRL*

(GR)28GVVGAGPGSTGQISKPVAT-GFP*

ATG-V5 GA/GP/GR CT

(GA)71 Cterminal 39 AAs

(GP)71 Cterminal 40 AAs

(GR)71 Cterminal 60 AAs

(GA)71GRGRVGAPWSGRARGRARGGAAVAVPAPAAAEAQAVASG*

(GP)71VVEGWARRGRGGPGGGPGAGLRLRCLRPRRRRRRRWRVGE*

(GR)71SWKGGRAVVGAGPGAGPGRGCGCGACARGGGGAGGGEWVSEEAASWRVAVWGSAAGKRRG*

ATG-V5 GA/GP/GR Δ CT

(GA)71 Cterminal 9 AAs

(GP)71 Cterminal 10 AAs

(GR)71 Cterminal 7 AAs

(GA)71GRGRVGAPE*

(GP)71VVEGWARLSE*

(GR)71 SWKGGRA*