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Table 1 RAN Translation Peptides in G4C2 repeat transgenic flies and plasmids

From: The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD

Genotype In (GA) n frame In (GP) n frame In (GR) n frame
C9ORF72 sense strand (GA) n Cterminal 31 AAs (GP) n Cterminal 34 AAs (GR) n Cterminal 54 AAs
(GA) nWSGRARGRARG GAAVAVPAPAAAEAQ AVASG* (GP)nGRGRGGPGGGPGAGLRLRCLRPRRRRRRRWRVGE* (GR)nGVVGAGPGAGPGRGCGCGACARGGGGAGGGEWVSEEAASWRVAVWGSAAGKRRG*
0+ (G4C2)28 GFP (GA)28 Cterminal253AAs(GFP) (GP)28 Cterminal 15 AAs (GR)28 Cterminal 258 AAs
(GA)28GAWSGRARDP PVAT-GFP* *(GP)28GRGRGGPGIHRSPPW* (GR)28GVVGAGPGST... AAYNHYK*
1+ (G4C2)28 GFP (GA)28 Cterminal 264 AAs (GP)28 Cterminal 258 AAs (GFP) (GR)28 Cterminal 20 AAs
(GA)28GAWSGRARDP... KRPRL* *(GP)28GRGRGGPGIHRS DLEPVAT-GFP* (GR)28GVVGAGPGSTGQISNRSPPW*
2+ (G4C2)28 GFP (GA)28 Cterminal 21 AAs (GP)28 Cterminal 264 AAs (GR)28 Cterminal 258 AAs (GFP)
(GA)28GAWSGRARDPPVRSRNRSPPW* *(GP)28GRGRGGPGIH.... KRPRL* (GR)28GVVGAGPGSTGQISKPVAT-GFP*
ATG-V5 GA/GP/GR CT (GA)71 Cterminal 39 AAs (GP)71 Cterminal 40 AAs (GR)71 Cterminal 60 AAs
(GA)71GRGRVGAPWSGRARGRARGGAAVAVPAPAAAEAQAVASG* (GP)71VVEGWARRGRGGPGGGPGAGLRLRCLRPRRRRRRRWRVGE* (GR)71SWKGGRAVVGAGPGAGPGRGCGCGACARGGGGAGGGEWVSEEAASWRVAVWGSAAGKRRG*
ATG-V5 GA/GP/GR Δ CT (GA)71 Cterminal 9 AAs (GP)71 Cterminal 10 AAs (GR)71 Cterminal 7 AAs
(GA)71GRGRVGAPE* (GP)71VVEGWARLSE* (GR)71 SWKGGRA*