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Table 1 Genomic alterations identified by NGS in each tumor component

From: A dual-genotype oligoastrocytoma with histologic, molecular, radiological and time-course features

Genomic Alteration Variant Allele Fraction or % mosaicism  
Gene DNA Change Protein Change Oligodendroglioma Astrocytoma Initial Resection
IDH1 c.395G > A (NM_005896.3) p.Arg132His 0.31 0.29 0.43
TERT c.-124C > T (NM_198253.2) p.? 0.23 0 0
CIC c.781_792del (NM_015125.4) p.Phe261_His264del 0.32 0 0
1p/19q co-deletion 35–45% not detected (< 30%) not detected (< 30%)
TP53 c.841G > A (NM_000546.5) p.Asp281Asn < 0.01 0.38 0.87
TP53 c.817C > T (NM_000546.5) p.Arg273Cys < 0.01 0.08 0.08
ATRX c.4744dup (NM_000489.4) p.Thr1582Asnfs*19 < 0.01 0.26 0.26
NOTCH1 c.1347C > G (NM_017617.4) p.Cys449Trp 0 0.18 0.18
PIK3CA c.3197C > T (NM_006218.3) p.Ala1066Val 0 0 0.05
MDM4 c.458A > G (NM_002393.4) p.Asp153Gly 0.39 0.44 0.44