Fig. 3

Quantification of p-PERK+ and p-eIF2α + neurons, tau load and beta-amyloid load in regions of the human olfactory system in normal and AD cases. The percentage of p-PERK+ neurons (a) and p-eIF2α + neurons (b) was determined in the AONb, AONi, piriform cortex, entorhinal cortex and CA1 region of AD and normal cases. There was a significant increase in both p-PERK and p-eIF2α for AD cases in all regions assessed. Tau load (c) and beta-amyloid load (d) for each region was determined as the % area of the image stained. Tau load was significantly increased in AD cases for all regions assessed. Similarly, the beta-amyloid load was significantly increased in AD cases for all regions except the AONi. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001 compared to normals in the same region